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An Amyloid beta (Abeta) vaccine that safely drives immunity to a key pathological species in Alzheimer’s disease: pyroglutamate Abeta

M. Vukicevic, E. Fiorini, S. Siegert, R. Carpintero, M. Rincon, P. Lopez-Deber, N. Piot, M. Ayer, I. Rentero, C. Babolin, S. Bravo-Veyrat, V. Giriens, C. Morici, M. Beuzelin, A. Gesbert, S. Rivot, S. Depretti, P. Donati, J. Streffer, A. Pfeifer, M. H. Kosco-Vilbois

Preclinical results of our wholly owned anti-Abeta vaccine program ACI-24 show that the optimized formulation generates a potent and sustained immune response. Antibodies showed binding to pyroglutamate Abeta, a highly neurotoxic form of Abeta, which, following recent proof-of-concept from a monoclonal antibody, is a promising target for Alzheimer therapy.

Brain Communications, https://doi.org/10.1093/braincomms/fcac022

Published: 04 February 2022

AC Immune's scientific publications

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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Smith R, Capotosti F, Schain M, Ohlsson T, Vokali E, Molette J, Touilloux T, Hliva V, Dimitrakopoulos IK, Puschmann A, Jögi J, Svenningsson P, Andréasson M, Sandiego C, Russell DS, Miranda-Azpiazu P, Halldin C, Stomrud E, Hall S, Bratteby K, Tampio L’Estrade E, Luthi-Carter R, Pfeifer A, Kosco-Vilbois M, Hansson O  
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Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

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An Amyloid beta (Abeta) vaccine that safely drives immunity to a key pathological species in Alzheimer’s disease: pyroglutamate Abeta

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15/10/2020 Gabellieri E et al. , Eur. J. Med. Chem., 2020

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Tau PET imaging with 18F-PI-2620 in patients with Alzheimer's disease and healthy controls: a first-in-human study

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Binding Affinity Measurement of Antibodies from Crude Hybridoma Samples by SPR

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Targeting the inflammasome pathway with an anti-ASC immunotherapy in Alzheimer’s disease

D. Basco
11/03/2024 Staffler G. et al., ADPD 2024

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Optimized ACI-24, an amyloid beta (Abeta) vaccine that safely drives immunity to oligomers and Pyroglutamate Abeta, key pathological species of Alzheimer’s disease

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Discovery of [18F]ACI-12589, a novel and promising PET-tracer for a-synuclein

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An optimized Amyloid beta vaccine that safely drives immunity to the key pathological species of Alzheimer's disease

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Optimization of PET tracers for TDP-43 proteinopathies

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