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Scientific publications

  • Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

    Mark Ultsch, Bing Li, Till Maurer, Mary Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W. Bainbridge, Mike Reichelt, James A. Ernst, Charles Eigenbrot, Germaine Fuh, Jasvinder K. Atwal, Ryan J. Watts, Weiru Wang

    2016 Scientific Reports | 6:39374 | DOI: 10.1038

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  • Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

    Clara Theunis, Oskar Adolfsson, Natalia Crespo-Biel, Kasia Piorkowska, Maria Pihlgren, David T. Hickman, Valerie Gafner, Peter Borghgraef, Herman Devijver, Andrea Pfeifer, Fred Van Leuven, Andreas Muhs

    2016 J. Alzheimer. Dis. 56, 585-599

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  • An Anti-Beta-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

    Pavel V. Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L. Nosheny, Alexander M. Kleschevnikov, Janice S. Valletta, Sara K. S. Bengtsson, Gordon R. Linke, Michael T. Maloney, David T. Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L. Pearn, Andrea Pfeifer, Andreas Muhs, William C. Mobley

    2016 PLOS one

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  • Antibody-mediated targeting of Tau in vivo does not require effector function and microglial engagement

    Seung-Hye Lee, Claire E. Le Pichon, Oskar Adolfsson, Valerie Gafner, Maria Pihlgren, Han Lin,Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan,James A. Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V. Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J. Watts, Andreas Muhs, Kimberly Scearce-Levie and Gai Ayalon

    2016 Cell Reports

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  • Synthesis and structure–activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of b-amyloid-42 aggregation

    Heiko Kroth, Nampally Sreenivasachary, Anne Hamel, Pascal Benderitter, Yvan Varisco, Valérie Giriens, Paolo Paganetti, Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs 

    2016 Bioorganic & Medicinal Chemistry Letters

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  • Binding Affinity Measurement of Antibodies from Crude Hybridoma Samples by SPR

    Dorin Mlaki Ndao, David T. Hickman, María Pilar López-Deber, Aurélien Davranche, Andrea Pfeifer, Andreas Muhs 

    2014 BioProtocol 

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  • Engineering Amyloid-Like Assemblies from Unstructured Peptides via Site-Specific Lipid Conjugation

    Maria Pilar Lopez Deber, David T. Hickman, Deepak Nand , Marc Baldus, Andrea Pfeifer, Andreas Muhs 

    2014 PLOS one

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  • Cognitive enhancers (Nootropics). Part 1: drugs interacting with receptors

    Froestl,W., Muhs,A., Pfeifer,A. 

    2014 Journal of Alzheimer's disease

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  • Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes.

    Froestl,W., Muhs,A., Pfeifer,A.

    2014 Journal of Alzheimer's disease 

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  • Cognitive enhancers (Nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. Disease-modifying drugs.

    Froestl,W., Pfeifer,A., Muhs,A. 

    2014 Journal of Alzheimer's disease

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  • Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis

    Paganetti P1, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A 

    2014 Journal of Alzheimer's disease

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  • Human genome-guided identification of memory-modulating drugs

    Papassotiropoulos A1, Gerhards C, Heck A, Ackermann S, Aerni A, Schicktanz N, Auschra B, Demougin P, Mumme E, Elbert T, Ertl V, Gschwind L, Hanser E, Huynh KD, Jessen F, Kolassa IT, Milnik A, Paganetti P, Spalek K, Vogler C, Muhs A, Pfeifer A, de Quervain DJ.

    2013 PNAS

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  • Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes

    Froestl,W., Muhs,A., Pfeifer,A.

    2013 Journal of Alzheimer's disease

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  • Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs

    Froestl,W., Pfeifer,A., Muhs,A.

    2013 Journal of Alzheimer's disease

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  • Dynamic nuclear polarization NMR spectroscopy: revealing multiple conformations in lipid-anchored peptide vaccines

    Koers E, López-Deber MP, Weingarth M, Nand D, Hickman DT, Mlaki Ndao D, Reis P, Granet A, Pfeifer A, Muhs A, Baldus M.

    2013 Angewandte Chemie International Edition

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  • Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

    Theunis C, Crespo-Biel N, Gafner V, Pihlgren M, Lopez-Deber P, Reis P, Hickman D, Adolfsson O, Chuard N, Mlaki Ndao D, Borghgraef P, Devijver H, Van Leuven F, Pfeifer A, Muhs A

    2013 PLOS one

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  • TLR4 and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T-cell independent isotype switch in mice

    Pihlgren M, Silva AB, Madani R, Giriens V, Waeckerle-Men Y, Fettelschloss A, Hickman D, Lopez-Deper MP, Mlaki Ndao D, Vukicevic M, Bucarello AL, Gafner V, Chuard N, Reis P, Piorkowska K, Pfeifer A, Kündig TM, Muhs A, Johansen P.

    2013 Blood

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  • An effector-reduced anti-ß-amyloid (Aß) antibody with unique Aß binding properties promotes neuroprotection and glial engulfment of Aß

    Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.

    2012 Journal of Neuroscience

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  • A C-linked disaccharide analogue of Thomsen-Friedenreich epitope induces a strong immune response in mice

    Awad, L., Madani, R., Gillig, A., Kolympadi, M., Pihlgren, M., Muhs, A., Gerard, C., Vogel, P.

    2012 Chemistry

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  • Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors

    Froestl, W., Muhs, A., Pfeifer, A.

    2012 Journal of Alzheimer's disease

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  • Distribution and binding of 18F-labeled and 125I-labeled analogues of ACI-80, a prospective molecular imaging biomarker of disease: a whole hemisphere post mortem autoradiography study in human brains obtained from Alzheimer's disease patients

    Gulyas,B., Spenger,C., Beliczai,Z., Gulya,K., Kasa,P., Jahan,M., Jia,Z., Weber,U., Pfeifer,A., Muhs,A., Willbold,D., Halldin,C.

    2012 Neurochemistry International

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  • Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

    Heiko Kroth, Annalisa Ansaloni, Yvan Varisco, Asad Jan, Nampally Sreenivasachary, Nasrollah Rezaei-Ghaleh, Valérie Giriens, Sophie Lohmann, María Pilar López-Deber, Oskar Adolfsson, Maria Pihlgren, Paolo Paganetti, Wolfgang Froestl, Luitgard Nagel-Steger, Dieter Willbold, Thomas Schrader, Markus Zweckstetter,
    Andrea Pfeifer,  Hilal A. Lashuel, and Andreas Muhs 

    2012 Journal of Biological Chemistry

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  • Development of a small D-enantiomeric Alzheimer's amyloid-beta binding peptide ligand for future in vivo imaging applications

    Funke,S.A., Bartnik,D., Gluck,J.M., Piorkowska,K., Wiesehan,K., Weber,U., Gulyas,B., Halldin,C., Pfeifer,A., Spenger,C., Muhs,A., Willbold,D.

    2012 PLOS one

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  • Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-(18F) fluorobenzoate and prelimniary examination by postmortem whole-hemisphere human brain autoradiography

    Jahan M, Nag S, Krasikova R, Weber U, Muhs A, Pfeifer A, Spenger C, Willbold D, Gulyás B, Halldin C

    2012 Nucl. Med. Biol.

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  • An historical perspective on GABAergic drugs

    Froestl,W.

    2011 Furture Med. Chem

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  • Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases

    Hickman DT, Lopez-Deber MP, Mlaki D, Silva AB, Nand D, Pihlgren M, Giriens V, Madani R, St-Pierre A, Karasteneva H, Nagel-Steger L, Willibold D, Riesner D, Nicolau C, Baldus M, Pfeifer A, Muhs A

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  • Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

    Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PF, Pfeifer A, Lahsuel HA.

    2011 Journal of Biological Chemistry

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  • Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

    Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, van der Auwera I, van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, Brady RO, Pfeifer A, Nicolau C

    2007 PNAS

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  • Novel GABA(B) receptor positive modulators: a patent survey

    Froestl,W.

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  • Chemistry and pharmacology of GABAB receptor ligands

    Froestl,W.

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  • Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells

    Gatouillat G, Odot J, Balasse E, Nicolau C, Tosi PF, Hickman DT, López-Deber MP, Madoulet C

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  • Induction of auto-antibodies to murine P-glycoprotein: consequences on drug sensitivity in MDR cancer cells and on the expression of mdr genes in organs

    Perrin L, Gatouillat G, Balasse E, Odot J, Nicolau C, Tosi PF, Madoulet C.

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  • Inhibition of multidrug resistance by immunisation with synthetic P-glycoprotein-derived peptides

    Pawlak-Roblin C, Tosi PF, Perrin L, Devy J, Venteo L, Albert P, Nicolau C, Madoulet C.

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  • A liposome-based therapeutic vaccine against beta-amyloid plaques on the pancreas of transgenic NORBA mice

    Nicolau C, Greferath R, Balaban TS, Lazarte JE, Hopkins RJ.

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  • Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system

    Spragg DD, Alford DR, Greferath R, Larsen CE, Lee KD, Gurtner GC, Cybulsky MI, Tosi PF, Nicolau C, Gimbrone MA Jr.

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  • Immune response against the murine mdr1 protein induced by vaccination with synthetic lipopeptides in liposomes

    Tosi PF, Radu D, Nicolau C

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