Scientific Publications

 

TLR4 and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T-cell independent isotype switch in mice
Pihlgren M, Silva AB, Madani R, Giriens V, Waeckerle-Men Y, Fettelschloss A, Hickman D, Lopez-Deper MP, Mlaki Ndao D, Vukicevic M, Bucarello AL, Gafner V, Chuard N, Reis P, Piorkowska K, Pfeifer A, Kündig TM, Muhs A, Johansen P
Blood  2013, 121:85-94
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation
Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, Lopez-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A
J. Biol. Chem., 287:34786-800

An effector-reduced anti-ß-amyloid (Aß) antibody with unique Aß binding properties promotes neuroprotection and glial engulfment of Aß
Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ
J. Neuroscience 2012, 32:9677-9689

Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-(18F) fluorobenzoate and prelimniary examination by postmortem whole-hemisphere human brain autoradiography
Jahan M, Nag S, Krasikova R, Weber U, Muhs A, Pfeifer A, Spenger C, Willbold D, Gulyás B, Halldin C
Nucl. Med. Biol. 2012, 39: 315-323
Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases
Hickman DT, Lopez-Deber MP, Mlaki D, Silva AB, Nand D, Pihlgren M, Giriens V, Madani R, St-Pierre A, Karasteneva H, Nagel-Steger L, Willibold D, Riesner D, Nicolau C, Baldus M, Pfeifer A, Muhs A
J. Biol. Chem. 2011, 286: 13966-13976

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species
Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PF, Pfeifer A, Lahsuel HA.
J. Biol Chem. 2011, 286:8585-96
Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice
Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, van der Auwera I, van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, Brady RO, Pfeifer A, Nicolau C
Proc. Natl. Acad. Sci. USA 2007, 104, 9810
Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells
Gatouillat G, Odot J, Balasse E, Nicolau C, Tosi PF, Hickman DT, López-Deber MP, Madoulet C.
Cancer Lett. 2007, 257,165
Induction of auto-antibodies to murine P-glycoprotein: consequences on drug sensitivity in MDR cancer cells and on the expression of mdr genes in organs
Perrin L, Gatouillat G, Balasse E, Odot J, Nicolau C, Tosi PF, Madoulet C.
Biochem. Biophys. Res. Commun. 2007, 358, 325
Inhibition of multidrug resistance by immunisation with synthetic P-glycoprotein-derived peptides
Pawlak-Roblin C, Tosi PF, Perrin L, Devy J, Venteo L, Albert P, Nicolau C, Madoulet C.
Eur. J. Cancer 2004, 40, 606
A liposome-based therapeutic vaccine against beta-amyloid plaques on the pancreas of transgenic NORBA mice
Nicolau C, Greferath R, Balaban TS, Lazarte JE, Hopkins RJ.
Proc. Natl. Acad. Sci. USA 2002, 99, 2332
Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system
Spragg DD, Alford DR, Greferath R, Larsen CE, Lee KD, Gurtner GC, Cybulsky MI, Tosi PF, Nicolau C, Gimbrone MA Jr.
Proc. Natl. Acad. Sci. USA 1997, 94, 8795
Immune response against the murine mdr1 protein induced by vaccination with synthetic lipopeptides in liposomes
Tosi PF, Radu D, Nicolau C.
Biochem. Biophys. Res. Commun. 1995, 212, 494